This comprehensive guide compares Centralized Finance (CeFi) and Decentralized Finance (DeFi) lending platforms to help crypto investors choose the optimal strategy for generating passive income. CeFi platforms offer user-friendly interfaces, stable yields of 5-10% APY, and regulatory compliance, making them ideal for beginners seeking simplicity. DeFi protocols like Aave, Morpho, and Compound provide non-custodial asset control, permissionless access, and variable yields ranging from 0.7% to 1.55% APY, appealing to experienced investors. The guide examines custody models, security frameworks, ease of use, interest rates, accessibility, and customer support across both ecosystems. Whether prioritizing convenience and stability through CeFi or autonomy and potential returns through DeFi, investors benefit from understanding these distinct lending models to implement diversified strategies aligned with their risk tolerance and technical proficiency in the evolving crypto lending market.