Gilead Sciences Demonstrates Efficacy in ARTISTRY-2 Trial as GILD Stock Gains Ground

TestnetNomad · 2025-12-26T04:59:37+00:00

Gilead Sciences reported positive results from its Phase 3 ARTISTRY-2 trial, showing that a new fixed-dose combination therapy for HIV is as effective as BIKTARVY. The study confirmed viral suppression and a favorable safety profile, enhancing Gilead's future regulatory submissions.

TestnetNomad

2025-12-26 04:59:37

Abstract generation in progress

Gilead Sciences (GILD) unveiled encouraging clinical data on Monday from its Phase 3 ARTISTRY-2 trial, a pivotal study examining the effectiveness of transitioning HIV patients to a novel fixed-dose combination therapy. The trial focused on patients with HIV who have achieved viral suppression and were evaluating a once-daily regimen combining bictegravir and lenacapavir as an alternative to the company’s established BIKTARVY treatment.

The trial results demonstrated that the new combination therapy achieved equivalent efficacy compared to BIKTARVY through the 48-week observation period. Study participants maintained consistent viral suppression levels, with the experimental regimen proving to be a viable switching strategy for virologically suppressed patients. Notably, the safety profile remained favorable throughout the trial period, with no unexpected adverse events identified.

The comprehensive ARTISTRY program, which now includes data from both the ARTISTRY-2 and ARTISTRY-1 trials, is poised to strengthen Gilead’s regulatory filing strategy. The company intends to leverage the combined evidence from both studies to support future submissions to health authorities and present findings at scientific conferences, bolstering the clinical case for the new therapeutic option.

Market sentiment reflected the positive developments, with GILD stock trading at $121.70, representing a gain of $2.09 or 1.75 percent during the session on the Nasdaq. The clinical validation of this combination approach underscores Gilead’s ongoing commitment to expanding treatment options for the HIV-positive population, particularly those seeking simplified, effective long-term management strategies.

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